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By J. Thomas August, M.W. Anders, Ferid Murad, Joseph T. Coyle (Eds.)

ISBN-10: 0120329360

ISBN-13: 9780120329366

Each one quantity of Advances in Pharmacology presents a wealthy choice of reports on well timed subject matters. Emphasis is put on the molecular bases of drug motion, either utilized and experimental.

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In the acute stages of the murine air pouch model of croton oil-induced chronic granulomatous inflammation COX activity progressively rose during the first 24 h accompanied by an increase in COX-2 protein. In the chronic phase of the inflammatory response COX activity was two to three times greater than in the acute stage. , 1994). A number of COX metabolites have been measured in this model and PGE2 was always proportionally greater at all time points measured > 6-keto PGFI, > TXBz > PGFh. Furthermore, the major source of COX-2 protein was the M+.

The minor elements include arsenic, cobalt, chromium, copper, fluoride, iron, iodide, manganese, molybdenum, nickel, selenium, silicon, tin, vanadium, and zinc. While these trace elements have important physiological functions, most are not important contributors to drugmineral interactions. Many drug-mineral interactions have little clinical importance. Malnourished individuals, the elderly, and patients with chronic diseases are more frequently viewed as having these interactions (Hussar, 1988; Smith and Bidlack, 1984; Hansten and Horn, 1989).

How diet affects drug metabolism. Hosp. Ther. April, 93. Bennett, W. , and Porter, G. A. Overview of clinical nephrotoxicity. In “Toxicology of the Kidney” 2nd ed, (J. B. Hook and R. S. ) Target Organ Toxicity Series, p. 61, Raven Press, New York. Cardinale, V. Stemming the tide of polymedicine. Drug Topics 132, 36. Chen, L. , Cook Newell, M. , and Barnes, K. (1985). Survey of drug use by the elderly and possible impact of drugs on nutritional status. Drug-Nutr. Interact. 3, 73. Childs, B. (1988).

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Advances in Pharmacology, Vol. 35 by J. Thomas August, M.W. Anders, Ferid Murad, Joseph T. Coyle (Eds.)

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