Anti-aging in Ophthalmology: Special Issue: Ophthalmic by K. Tsubota PDF

By K. Tsubota

ISBN-10: 3805595743

ISBN-13: 9783805595742

A number of the ailments resulting in blindness similar to cataract, glaucoma, diabetic retinopathy and age-related macular degeneration correlate with the patient's age. Even genetic problems equivalent to retinitis pigmentosa could be thought of 'premature getting older of the retina', and extra, dry eye or presbyopia, that may dramatically impact caliber of imaginative and prescient, are age comparable. Antiaging examine turns into progressively more vital nowadays, even if the basics should not but normal ordinary within the medical institution; despite the fact that, reactive oxygen species keep watch over appears to be like the start. sooner or later, a formal vitamin, together with calorie restrict or antioxidant foodstuff elements, antioxidant supplementations, workout in addition to drug intervention may possibly play an important function within the fight opposed to age-related eye issues. This quantity exhibits the newest advancements and may be a important replace just about age-related eye ailments not just for ophthalmologists, but in addition for common physicians.

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Karger AG, Basel © 2010 S. com/ore Introduction Glaucoma is an optic neuropathy characterized by the accelerated death of retinal ganglion cells and their axons.  1) across all populations [1, 2]. While glaucoma has traditionally been considered a disease of raised intraocular pressure (IOP), the increase in disease prevalence with age is not accompanied by a corresponding increase in IOP [3]. Furthermore, not all ocular hypertensive patients develop glaucoma, not all glaucoma patients have elevated IOP, and lowering IOP does not always prevent vision loss in glaucoma patients.

The insults that predispose aged retinal ganglion cells to injury are likely to be varied and multiple; therefore, it may be more relevant to identify and treat common mechanisms that predispose to retinal ganglion cell failure and/or death. We suggest that mitochondrial dysfunction, as either a cause or consequence of injury, renders retinal ganglion cells sensitive to degeneration. Therapeutic approaches that target mitochondria and promote energy production may provide a general means of protecting aged retinal ganglion cells from degeneration, regardless of the etiology.

The first identified mitochondrial disease associated with the dNTP pool is mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), which is characterized by ocular defects such as ophthalmoplegia and pigmentary retinopathy [54]. It is of further interest to note that nucleotide imbalance, such as that observed in MNGIE, is highly mutagenic and has the potential to impair the DNA repair processes [55]. Mitochondrially Generated ROS Mitochondria account for the bulk of endogenously formed ROS in most cells [17, 56, 57] with the mitochondrial respiratory chain acting as the major intracellular source of ROS [58–60].

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Anti-aging in Ophthalmology: Special Issue: Ophthalmic Research 2010, Vol. 44, No. 3 by K. Tsubota


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